Source code for cameo.strain_design.pathway_prediction.util
# Copyright 2015 Novo Nordisk Foundation Center for Biosustainability, DTU.
# Licensed under the Apache License, Version 2.0 (the "License");
# you may not use this file except in compliance with the License.
# You may obtain a copy of the License at
# http://www.apache.org/licenses/LICENSE-2.0
# Unless required by applicable law or agreed to in writing, software
# distributed under the License is distributed on an "AS IS" BASIS,
# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
# See the License for the specific language governing permissions and
# limitations under the License.
from __future__ import absolute_import, print_function
import re
from cobra import Reaction
from cameo.ui import notice
from cameo.util import in_ipnb
try:
from IPython.display import display
except ImportError:
pass
__all__ = ['create_adapter_reactions', 'display_pathway']
[docs]def create_adapter_reactions(original_metabolites, universal_model, mapping, compartment_regexp):
"""Create adapter reactions that connect host and universal model.
Parameters
----------
original_metabolites : list
List of host metabolites.
universal_model : cobra.Model
The universal model.
mapping : dict
A mapping between between host and universal model metabolite IDs.
compartment_regexp : regex
A compiled regex that matches metabolites that should be connected to the universal model.
Returns
-------
list
The list of adapter reactions.
"""
adapter_reactions = []
metabolites_in_main_compartment = [m for m in original_metabolites if compartment_regexp.match(m.compartment)]
if len(metabolites_in_main_compartment) == 0:
raise ValueError('no metabolites matching regex for main compartment %s' % compartment_regexp)
for metabolite in metabolites_in_main_compartment: # model is the original host model
name = re.sub('_{}$'.format(metabolite.compartment), '', metabolite.id) # TODO: still a hack
mapped_name = None
for prefix in ['bigg:', 'kegg:', 'rhea:', 'brenda:', '']: # try no prefix at last
if prefix + name in mapping:
mapped_name = mapping[prefix + name]
break
if mapped_name is not None:
adapter_reaction = Reaction(str('adapter_' + metabolite.id + '_' + mapped_name))
adapter_reaction.lower_bound = -1000
try:
adapter_reaction.add_metabolites({metabolite: -1,
universal_model.metabolites.get_by_id(mapped_name): 1})
except KeyError:
pass
else:
adapter_reactions.append(adapter_reaction)
return adapter_reactions
[docs]def display_pathway(pathway, i):
notice("Pathway %i" % i)
if in_ipnb():
display(pathway.data_frame)
else:
print(pathway.data_frame)